Drug name] pralidoxime chloride
[English name] Pvraloximi Chloridum
[alias] chloride phosphorus pralidoxime chloride, PraHdoximeMethytchloride, 2, a PAM - Cl, Portopam [molecular formula] C7H9ON2CL [Characteristics] crystalline powder is yellowish white; no olympic. Easily soluble in water, slightly soluble in ethanol, practically insoluble in chloroform or ether. 2.87% aqueous solution of isotonic solution.
[pharmacological action] this product is organic phosphorus poison solution. Because of its molecular structure containing quaternary ammonium groups, can be combined with organic phosphorus free, be nontoxic compounds excreted; can also restore the cholinesterase activity, but the poisoning time more than 36 hours, the product recovery effect is poor.
[indications] the product used in the rescue of acute organophosphate poisoning, but its role in the restoration of cholinesterase according to organic phosphorus varieties with different and not equal: for the good effect of parathion, Demeton, phorate, methamidophos, Trapp; trichlorphon, dichlorvos of poor curative effect of dimethoate, malathion effect; suspicious; has adverse effect on two azinphos methyl, diazinon. At the same time, the product can also be combined with atropine, eliminate acetylcholine produced in vivo toxicity of savings.